I am a Naturopathic Physician, not a biochemist, but I think we need to discuss the Biochemical, Biophysical, and Quantum mechanisms of Ozone therapy. These ideas are based upon my own personal Left Brain imaginations of the information I have read. They may have some insight is designing and delivering therapy even if they are not totally complete or correct. I welcome comments and corrections as this is what drives knowledge forward.
Ozone is not Oxygen. And electrons are not particles like tiny planets revolving around the Sun-like nucleus. That mid-evil concept went out with the Uncertainty Principle…electrons are now an electron cloud. We live in a Quantum Universe; We are Quantum Beings. Oxygen flows with the blood; electrons do NOT flow with the blood. When we introduce or shoot electrons into the body, the electron cloud fills the entire body immediately.
Being a Naturopathic Physician and trained in Homeopathy, I believe in the Magic of the Minimal Dose! Some other people, and other schools of medicine, like to get a bigger hammer. This is similar to dosing in alkaloidal medicine where the minimal amount has a stimulating effect, a medium amount has an increasing suppressive effect until you reach the toxic dose which is the large toxic amount.
Ozone has at least two therapeutic mechanisms of action. Most of the research on Ozone has been looking into the destructive effect of environmental ozone and the destructive effect we call aging. We know Ozone is a powerful oxidant causing free radical lipid peroxidation. In this process, Ozone will interact with a double bond, stealing an electron from the double bond converting the double bond to a single bond while releasing another free electron. This is a chain reaction, the electron does not get used up, but goes on and on repeating this same process again and again. This is what disinfects or purifies water. This is what kills membrane virus like flu or CoV at extremely low concentrations. O.5% hydrogen peroxide will kill a membrane virus in 1 minute. 7.5% H2O2 is used as an FDA approved medical disinfectant on external surfaces effective against viruses, bacteria, fungus, molds, and spores.
Ozone also has a marvelous therapeutic healing effect restoring and balancing all kinds of cellular function. Amazing. Ozone is known to induce a long-term enhancement of Oxygen utilization. Oxygen itself does not enhance Oxygen utilization. Ozone has an extra free electron, Oxygen does not. Although true, Ozone converts to Oxygen within nanoseconds upon entering the blood, this statement alone generates confusion, ignorance, and potential harm if you forget about the ELECTRON!
Free radical lipid peroxidation, the destructive action, is a chain reaction; the electron does not get used up but goes on to do more free radical damage until it is squelched by the antioxidant pathways or is eaten by a mitochondria. The antioxidant vitamins can capture the electron and can deliver it to where it is needed biochemically. Antioxidant enzymes assist in these processes.
Mitochondria have an electron transport chain that produces ATP for the eukaryote host cell. If you feed mitochondria Oxygen and electrons along with adequate nutrition of vitamins, minerals, and co-factors, the mitochondria will poop out ATP, a mitochondrial waste. Mitochondria have their own single-strand DNA and their own life cycle. With Ozone, Oxygen, and electrons, the mitochondria are well fed, happy, and healthy. Happy and healthy mitochondria have little Mitochondrial Babies. Happy and healthy Mitochondrial Babies rejuvenate the symbiotic energy-producing “powerhouse” of the cell. More life energy feels great and promotes life itself.
IMHO this is a very beneficial effect of Ozone therapy. For this goal, we do not want to burn up the mitochondrial lipid membranes with excess concentrations of ozone beyond the body’s ability to protect the host cells. The antioxidant pathways will deliver the electrons to where they are needed safely. So I preload with antioxidant pathway nutrition. These antioxidant vitamins are electron carriers; they do not harm the rejuvenation effect; they protect and support the mitochondria. Preloading with antioxidants captures the free electrons and delivers them where they are used biochemically.
I prefer to preload with antioxidants to protect and support the mitochondria, blood vessels, and nerves. By preloading with antioxidants you can tolerate higher doses. The antioxidants will not protect a virus and will not add any protection to microbes that can manufacture their own Vitamin C. Humans need to eat Vitamin C since we can not make our own.
Ozone is also known to build up the antioxidant enzymes. Best to Start low and go slow. As we build up the antioxidant enzymes, we can tolerate a higher concentration of Ozone. For support, start with a high-quality multiple vitamin and mineral supplement and then add supplementation of the antioxidant nutrients, and other nutrients to build up mitochondrial support and protection.
Direct intravenous use of Ozone (DIV) is clinically very commonly used safely and effectively. DIV at a safe and effective dose has significant advantages. When we introduce or shoot electrons into the body, the electron cloud fills the entire body immediately. This gives an immediate disinfection effect and an immediate mitochondrial boost throughout the whole body and mind, not just in an external bottle. DIV we can start low and go slow while building up the mitochondrial support.
Molecular Hydrogen gas, a selective anti-oxidant, is the other side of balancing and protecting cellular REDOX reactions.
Although Ozone does balance the immune system, the virucidal and antimicrobial effect is an electrochemical reaction independent of the immune system. This is the same way Ozone purifies water.